Evaluation and Significant Correlation of Serum Lipid Profile and Alanine Transaminase Levels in Drug Addict Individuals During Rehabilitation

Abstract

Background: Drug addiction is a significant global health concern, particularly due to its impact on liver function and lipid metabolism.

Objectives: This study investigates the alterations in serum lipid profiles and alanine transaminase (ALT) levels and showing their correlation in drug-addicted individuals undergoing rehabilitation.

Methods: A cross-sectional study was conducted on 50 male drug addicts aged 15 to 63 years and a control group of 50 healthy males. Blood samples were collected and analyzed using the Roche Cobas C311 chemistry analyzer to measure serum lipid profiles and ALT levels.

Results: Drug-addicted patients exhibited significantly lower levels of total cholesterol, triglycerides, HDL, and LDL compared to the control group across all age ranges. Conversely, ALT levels were consistently higher in the drug-addicted group, indicating potential liver impairment. Strong positive correlations were found between age and lipid parameters (cholesterol, HDL, LDL), with weaker correlations for triglycerides and ALT.

Discussion: The findings suggest that drug addiction leads to significant alterations in lipid metabolism and liver function. The reduced lipid levels and elevated ALT observed in drug addicts align with previous studies, reinforcing the association between substance abuse and metabolic disturbances. The elevated ALT levels, particularly in younger individuals, highlight the potential for early liver damage in drug users.

Conclusion: This study underscores the need for regular monitoring of lipid profiles and liver enzymes in drug-addicted individuals, particularly those in rehabilitation, to mitigate long-term health risks. The results provide valuable insights into the physiological impacts of drug addiction and emphasize the importance of comprehensive care in addiction treatment programs.